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A construct containing CAG-loxP-STOP-loxP-Kozak-GFP-Mito-TGA-pA was targeted to Rosa26 of the mouse Gt (ROSA) 26 S

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This is consistent with the reported contribution of the IGF axis to ICB resistance 19 , although re-testing in larger cohorts will be required to confirm this finding

NAM transporters have also been investigated and recently identified as SLC29A1 and SLC29A2, which are also able to transport NR 73

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