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The preclinical evidence compiled in animal models, however, offers a highly dependable, reproducible dataset demonstrating accelerated soft tissue remodeling, localized capillary formation, and cellular matrix organization

The effects of these issues are difficult to quantify, such that their interpretation is left to the users professional judgement, e.g., using qualitative pedigree matrices 45

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Preclinical research has examined its role in promoting angiogenesis, reducing oxidative stress in intestinal tissue, and interacting with the nitric oxide system to modulate gut blood flow

N., Brutsaert, T

First, they urge researchers to give importance to N-terminal modifications as key determinants of receptor activity and internalization