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The basolateral/sinusoidal membrane of hepatocytes contains several bile acid transporters to absorb bile acids from sinusoidal blood, including Na + -taurocholate co-transporting polypeptide NTCP (encoded by SLC10A1 ), OATP1B1 and OATP1B3 (encoded by SLCO1B1 and SLCO1B3 , respectively) [12, 15]

In mammalian ageing models, particularly D-galactose-induced mice, polysaccharide supplementation consistently increased SOD, CAT, and glutathione peroxidase (GPx) activities by 2045%, reduced malondialdehyde (MDA) by 2540%, and improved learning ability and physical performance [32,132,133]

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In vitro studies further validated these findings, showing that plasma from inflamed patients (e.g., PD patients with peritonitis) induces eryptosis in healthy donor RBCs