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Similarly, Pb 2 can substitute for Ca 2 in cell wall stabilization and intracellular signaling, resulting in chlorosis, necrosis, and biomass reduction

Brain Pathol 23(3):274284

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AICAR is phosphorylated by cellular kinases to form ZMP, which acts as an AMP mimetic that directly binds and activates AMPK [42, 43]

Saffron and crocin exert neuroprotective effects by reducing oxidative stress and inflammatory responses, which shows their potential for mitigating inflammation-related damage in patients with brain injury [71]