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Myocardial hypertrophy is a complex adaptive response characterized by increased cardiomyocyte volume and ventricular wall thickening, with both physiological and pathological manifestations (161)

It disrupts the growth cycle, accelerates miniaturization, and can lead to permanent follicle death

Atherosclerosis , 119 (1), 99106

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Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy

Within this context, GPX4 is considered an important core regulatory factor connecting redox imbalance, lipid peroxidation, and joint tissue degeneration