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identified two new ALA metabolites, 9( Z )-13,16-DiOH-12(15)-EpOME and 9( Z )-7,13,16-TriOH-12(15)-EpOME, 247 and three new GLA metabolites, 6( Z ),9( Z )-12(17);13(17)-DiEpODE, 6( Z ),9( Z )-12,13,17-TriHODE, and 6( Z ),9( Z )-12-OH-13(16)-EpODE

Nature 306 , 194196 (1983)

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This study found that under fasting conditions, SREBP2 upregulates FDFT1 expression, while elevated FDFT1 expression negatively regulates the AKT/mTOR/hypoxia-inducible factor-1 (HIF-1) signaling pathway, thereby inhibiting glycolysis and proliferation in CRC cells (80)

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Apart from increased intracellular iron load, ferroptosis is also characterized by excessive lipid peroxidation and reduced expression and function of antioxidant defense genes, particularly glutathione peroxidase 4 (Gpx4) and system Xc(Xct) [11]