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This results in cell cycle arrest in the S phase along with mitochondrial apoptosis (Lee et al., 2018

Conditions that impair MMC functionlike diabetes, hypothyroidism, or opioid usecan allow bacteria to linger and overgrow

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Collectively, the gut microbiota profile of the VPA-ASD groupmarked by an elevated Firmicutes/Bacteroidota ratio and an increase in pathobionts like Desulfovibrionalesaligns with established dysbiotic features of ASD

MittlerR.VanderauweraS.GolleryM.Van BreusegemF.2004Reactive oxygen gene network of plants,490498,1360-1385 81

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