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Both decline with age, stress, toxins, poor sleep and diet and can be boosted through IV therapy, lifestyle changes and oral supplements

Neurological abnormalities: Cognitive dysfunction, learning disability, developmental delay, macrocephaly (large head size), and dural ectasia (ballooning of the dural sac around the spinal nerves) are reported

Maintenance dosing drops to 2mg once weekly or less frequently

Glutamate homeostasis refers to the homeostatic regulation of non-synaptic primarily glial extracellular glutamate by cystineglutamate exchange and glutamate uptake, and the impact of this glutamate on pre- and postsynaptic metabotropic glutamate receptors in terms of regulating synaptic efficiency and plasticity

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