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Post-translational modification analysis For MS analysis of PDHc-E2 or OGDHc-E2 modifications, immunoprecipitation eluates were separated on a pre-cast 4% to 12% NuPAGE gel (Thermo Fisher Scientific, NP0321BOX) and protein bands were stained using SimplyBlue SafeStain solution (Thermo Fisher Scientific, LC6060)

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Some, but not all, studies in mouse models of Huntingtons disease have suggested that coenzyme Q 10 supplementation could improve motor performance, overall survival, and various hallmarks of Huntington's disease, i.e., brain atrophy, ventricular enlargement, and striatal neuronal atrophy (70, 71)

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