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Additionally, numerous factors like stress, unhealthy lifestyles, and pollutants can accelerate this process, causing bouts of exhaustion in affected individuals

Harnessing this pathway has therefore been of significant therapeutic interest

10.1002/ptr.5372 [DOI] [PubMed] [Google Scholar] Jin H., Qiao F., Wang Y., Xu Y., Shang Y

Preclinical studies utilizing FXN -silenced motor neurons and patient-derived cells have demonstrated that the FXN gene promoter contains highly conserved AREs, meaning Nrf2 directly drives FXN transcription in vitro [128,131,132]

doi: 10.1111/j.1600-6143.2011.03846.x 42 GriesemerAYamadaKSykesM