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Phenobarbital 296 Patients 1 Prospective Trial [1] One prospective RCT with phenobarbital 10mg/kg vs placebo (+symptom-triggered lorazepam for both groups) showed significant decrease in both ICU admission rate and continuous lorazepam infusion use (1 single center trial, results have not been duplicated) 1 Retrospective Trial [2] Propofol 225 Patients 5 Retrospective Trials [3 7] 1 Case Series [8] 3 Case Reports [9 11] Dexmedetomidine 6 Retrospective Trials [6 7

[22] The injections are usually given in a clinic setting, but in some cases patients may be taught to self-administer at home under medical guidance

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