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Remoxipride was discontinued after 8 cases (2 fatal) of aplastic anemia were detected

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The underlying cause of this disorder is a polymorphism in the promoter region of the UGT isoform 1A1 gene ( UGT1A1*28 ) that increases the length of the promoter [97]

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This effect was achieved through the activation of AMPK, PGC-1, and SIRT1 in muscle, increasing citric acid synthetase activity and improving mitochondrial efficiency