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Typical probiotics such as Lactobacillus and Bifidobacterium can improve metabolic efficiency and reduce oxidative stress and inflammation (154), and the proliferation of harmful bacteria (such as Enterococcus and Streptococcus ) can produce toxins (such as hemolysins and cytotoxins) or stimulate the intestinal immune system, leading to local or systemic inflammatory responses (155)

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The human virome is primarily composed of phages that can infect and lyse bacteria in the gut, and Myoviridae, Podoviridae, Siphoviridae, and Microviridae are present dominantly