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Repeated attempts to engineer an enzymatically dead kinase via a D135A mutation were unsuccessful, strongly suggesting that this kinase and its enzymatic activity are vital for animal viability

Caveolin-1 ( CAV1 gene) is ubiquitously expressed, but shows high expression in adipocytes, fibroblasts, pneumocytes, neurons, glia, endothelial and epithelial cells [42]

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Lamotrigine has a lower risk of weight gain and is generally better tolerated cognitively, but requires slow titration and carries a risk of serious rash

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