foxo4 dri senolytic peptide 2023 Frontiers Molecular modelling of the FOXO4-TP53

Among the dozens of compounds studied in pre-clinical and early research settings, two names consistently rise to the top of scientific literature and researcher discussions: BPC 157 (Body Protection Compound 157) and TB 500 (Thymosin Beta-4 Fragment)

[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Jajoo S.S., Zamwar U.M., Nagrale P

With better brain function, youre more likely to engage in movement, eat well, and sleep deeplyall of which are vital for an efficient metabolism

PMID: 39389052 Neuron 2024 Nov 6;112(21):3651-3664.e8

Oxidative stress results from an imbalance between free radicals and antioxidants in the body, leading to cellular damage and inflammation

It displaces p53 from the FOXO4 complex, leading to nuclear exclusion of p53 and activation of the intrinsic apoptosis pathway in the senescent cell