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Lipids 2013, 167168, 2132

J.RubioM.OlmosE.GarcaJ

Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells

Scarbrough et al., 2012)
mPEGPLGA NPs containing DETA NONOate mPEGPLGA and PLGA NPs encapsulating DETA NONOate were prepared using the modified double emulsion (water-in-oil-in-water) method, as previously reported (Figure 2)
