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There may be increased inflammation in the small intestine from increased mast cell activity

The use of leucovorin is based on research suggesting that many people with autism have a metabolic difference that could reduce the amount of folate that reaches the brain

Yet, the benefit of B-vitamin supplementation in primary prevention (i.e., in non-antiplatelet users) remains to be established

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Although this anti-inflammatory mechanism can facilitate recovery, excessive immune suppression may result in immune paralysis, leaving patients vulnerable to infections, delayed wound healing, and late-stage organ failure [21,24]

As a limitation, the study eliminated other databases like Google Scholar and Scopus, which would have had an impact on the quantity of papers returned, and we only used the Web of Science database
