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Toxicol in Vitro 40:248255

The data on rhIGF-1 support the mechanistic rationale that an IGF-1 analog like LR3 (which has extended half-life and greater receptor availability in research settings) could enhance protein synthesis, stimulate cellular proliferation pathways and promote more efficient nutrient partitioning, though direct clinical trials of IGF-1 LR3 itself in humans are lacking

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The prominence of hydrophobicity-related descriptors and normalized van der Waals volume terms is consistent with current understanding of BBB-relevant peptide properties, in which penetration is shaped by a constrained balance of polarity, compactness, residue packing, and surface chemistry ( Several limitations should be acknowledged