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Therefore, subsequent analyses were performed on the remaining 12 Cases and 9 Controls

Oxid Med Cell Longev 2021(1):6680935 Cunha-Oliveira T et al (2020) Oxidative stress in amyotrophic lateral sclerosis: pathophysiology and opportunities for pharmacological intervention

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GSH production is supported by NRF2 through controlling several enzymes responsible for GSH synthesis, such as the glutamate-cysteine ligase (GCL) complex composed of two subunits, the modifier (GCLM) subunit and the catalytic (GCLC) subunit, which catalyze the rate-limiting step of GSH synthesis that converts cysteine and glutamate into GSH [22]

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