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Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation

doi: 10.1038/s41380-022-01741-1

J Neurochem

[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Ma J., Hu Z., Yue H., Luo Y., Wang C., Wu X., Gu Y., Wang L

Yano S, Kuroda S, Shichinohe H, et al

Furthermore, the elucidation of the viral entry mechanism through mGluR2, due also to its predominant expression in brain tissues, unlike the recognised internalising receptor ACE2, may provide insights into the severe impact of COVID-19 on the brain and its intricate relationship with astrocyte damage, aberrant neuroinflammation, excitotoxicity, impairment of the glymphatic system as well as DLPFC and hippocampal injury [18, 233, 239]