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Your healthcare provider can offer tips to minimize any pain during administration

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Via a reaction catalyzed by the enzyme creatine kinase, creatine is in equilibrium with creatine phosphate, which effectively serves to buffer cellular ATP concentrations during periods of acute demand for large amounts of energy such as depolarization or contractile events

Fan et al., 2013

Moreover, other specialized mitochondria-residing proteins, such as the apoptosis inducing factor (AIF) and endonuclease G, are translocated to the nuclei following their release from mitochondria and promote peripheral chromatin condensation and high molecular weight DNA fragmentation