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Also, in the late phase of M1 macrophage polarization, lactate-derived lactylation of histone lysine residues as observed in conditions of hypoxia and bacterial challenges served as an epigenetic modification that directly stimulated the expression of homeostatic genes that have been traditionally associated with M2-like macrophages (Zhang et al., 2019)

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Bipolar disorder is also characterized by mutations to mtDNA and mitochondrial dysfunction caused predominantly by excess ROS (Andreazza et al

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Materials and Methods In this narrative review, we collected available peer-reviewed articles that addressed the antitumor effect of lactoferrin through its effect on iron

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