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The fact that GSH production is required during conditions that cause overproduction of ERgenerated ROS suggests a role for GSH in their elimination

In-vitro experiments examined the impact of NAC (3 mg) on red cells (30 ml) in the absence of liver tissue

Zhang N, Gao M, Wang ZH, et al

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These data suggest that in chronic alcoholics with liver disease, GSH deficiency exists, which may predispose to further liver toxicity caused by resultant inadequate defense mechanisms