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The fact that acetyl-CoA breakdown may be dependent on the availability of propionic acid when this alternative pathway is upregulated means that -oxidation may be stoichiometrically inhibited if propionic acid is not available

These methods, particularly LC-MS, are favored for their exceptional sensitivity, selectivity, and resolution

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Inclusion of a triantennary N -acetylgalactosamine (GalNAc 3 ) complex conjugated to the oligonucleotide or siRNA, enhances liver specificity resulting in greater potency at lower doses as well as reduced systemic toxicity (Table 2) [68]

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