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Filatova et al

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Ex vivo cytotoxicity assay NIH/3T3 cells, transfected with FAP protein, were used as target cells

In the years immediately following the IOMs 1998 report setting the current RDA, research associated an abnormally high level of homocysteine, a molecule involved in protein metabolism, with an increased risk of cardiovascular disease, mortality, and cognitive impairment

When these conversions don't happen, then the body's blood stream is overloaded with a form of B12 it can't use or clear very quickly (hence you feel very bad afterwards)