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Aberrant IGFs signaling may lead to malignant transformation and tumor progression, thus providing the rationale for targeting IGF axis in cancer
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Importantly, MCR agonists fail in mitigate alcohol intake on mutant mice lacking MC4Rs (Navarro et al., 2011), unveiling the fundamental role of this receptor in dependency and behavioral response to alcohol (Navarro et al., 2011)
doi: 10.1093/ajcn/76.6.1302
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