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In animals given the antioxidant N-acetylcysteine, calsequestrin-1 knockout reduced mitochondrial superoxide production while increasing glutathione levels in comparison to the control group (Michelucci et al., 2015)

doi: 10.1074/jbc.M114.554451

Grant S, Cragg L, Feldman E, Andreeff M , Roberts J, Tombes MB, Winning M

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Conventional therapies provide symptomatic relief, nevertheless, disease-modifying treatments that reduce or halt neuron death and malfunction are still largely unavailable