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TGNs are the active metabolites of 6-MP which produce cytotoxic activity, specifically by inducing apoptosis in active T-cells

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The ALDH1L1 encoded enzyme is localized to the cytosol and the ALDH1L2 encoded enzyme is localized to the mitochondria

Interactions between the cannabinoid and dopaminergic systems: evidence from animal studies

G protein-coupled receptor G protein-coupled receptors ( GPCRs ), also known as seven-(pass)-transmembrane domain receptors , 7TM receptors , heptahelical receptors , serpentine receptors , and G protein-linked receptors ( GPLR ), form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses

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