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An initial study with a limited sample size (39 HAPE patients and 43 controls) revealed no role of CYBA in HAPE pathogenesis in Caucasians, 119 but a larger Indian cohort (150 HAPE patients and 180 controls) linked CYBA (rs4673 and rs9932581) and GSTP1 (rs1695 and rs1138272) to elevated circulating 8-iso-prostaglandin F2 in HAPE, potentially contributing to HAPE susceptibility
Epigallocatechin gallate (EGCG), a major polyphenol in green tea, mitigates amyloid-beta production by inhibiting -secretase (BACE1) activity

It binds to neuroligins and actin and regulates actin polymerization, growth cone motility, dendritic spine morphology, and synaptic transmission [283]

In: SigelASigelHSigelRKO, editors

Science 339 , 197200 (2013)
doi: 10.1111/j.1467-7652.2011.00634.x 235 SaadA
