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However, a number of studies have indicated that peroxisomal -oxidation has a significantly lower capacity than that of mitochondrial -oxidation, particularly in muscle ( Reference Henderson and Tocher 63 Reference Fryland, Lie and Berge 65 )

Disparate results are likely due to study design issues, often linked to a lack of understanding of vitamin C pharmacokinetics and requirements (19, 20)

Despite claims that L-carnitine or ALCAR might increase seizures in some individuals with seizure disorders (133), these are not supported by any scientific evidence (134)