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The immunogenicity of LNPs is effectively ameliorated by incorporating dexamethasone as an antiinflammatory agent, ursolic acid as a VATPase agonist, budesonide as a partial replacement of cholesterol, thiodigalactoside or olitigaltin as galectin inhibitors, and using 4A3SC8 as a unique ionizable lipid limiting endosomal damage [82, 84, 184], and these strategies can be extrapolated to other inhaled nanoparticles

According to this classification system, gliomas can be divided into adult diffuse gliomas, diffuse low-grade gliomas in children, diffuse high-grade gliomas in children and localized astrocyte gliomas

For instance, acetylation of lysine residues on histones H3 and H4 is associated with gene activation, while methylation can either activate or repress gene expression depending on the site and degree of modification