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Studies in this systematic review support B12 supplementation for the treatment or prevention of metformin-induced deficiency and neuropathy, demonstrating increased levels of B12 and decreased serum homocysteine with supplementation

i , RER, j , oxygen consumption, k , food intake, l , weight loss and m , blood glucose of ob/ob mice following a single s.c

The Gut Microbiome and the GutBrain Axis The relationship between the gut microbiome and the brain is facilitated by a bidirectional connection called the gutbrain axis [11]

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