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Description
We identified upregulated lipid metabolism in progranulin-knockdown human induced pluripotent stem cells and in their differentiated microglia cells
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This structural observation is confirmed by Gs signaling data of the D122S variant that displays a total loss of Gs signaling upon stimulation with setmelanotide, but only a slight reduction for NDP--MSH (Fig
doi: 10.1074/jbc.M110.115097
McCort MN, Oehler C, Enriquez M, Landon E, Nguyen CT, Pettit NN, et al
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