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The endogenous antioxidant enzymatic system has evolved to control the detrimental effects of free radicals in the ear, including increased levels of antioxidant enzymes, such as copper/zinc and manganese superoxide dismutases (SOD1 and SOD2, respectively), catalase, GSH-related enzymes (glutathione peroxidases (GPxs), glutathione transferases (GSTs), and glutathione reductase), and peroxiredoxins (PRDXs)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 152.Gonzlez-Surez M., Aguilar-Arnal L

Peroxisome proliferator-activated receptor- ligands reduce inflammation and infarction size in transient focal ischemia

& Olynyk, J

Treatment for minor vitamin E toxicity includes discontinuing the use of your vitamin E supplement, but more serious complications may require medical intervention