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A high fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain
Beyond editing, strategies are being developed to selectively remove large portions of mutated mtDNA by reconstituting double-strand break repair pathways within mitochondria, potentially eliminating deletion-bearing genomes (171)
M.JemthP.WiderstenM.MannervikB
By making abrupt opioid discontinuation (quitting cold turkey) more comfortable and more successful
[PMC free article: PMC4127523] [PubMed: 25098735] 222
PGC-1 functions as a transcriptional coactivator for the retinoid X receptors
