lynch syndrome endometrial glutathione - Cancer Pathway Supporting Documents Hereditary Endometrial Cancer: Lynch Syndrome
Description
The evidence for the possible predictive nature of GSH is seen in large studies utilizing the more common biomarker gamma-glutamyl transferase (GGT) and its correlation with increased all-cause mortality

STRUCTURE Glutathione is a tripeptide consisting of three amino acids: glutamate, cysteine, and glycine, hence, described as -l-glutamyl-l-cysteinylglycine [Figure 1].[] INTRACELLULAR DISTRIBUTION OF GLUTATHIONE Glutathione is synthesized from glutamate, cysteine, and glycine in the cytosol

Biochimica et Biophysica Acta (BBA)-General Subjects, 1830(5), 3143-3153

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Its a potent antioxidant which is produced by the liver
While the status of screening for these polymorphisms remains to be established, uncovering the molecular mechanisms responsible for the dysregulation in GSH synthesis may provide novel therapeutic approaches
