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B12 Vitamin B12 is a water-soluble vitamin that helps keep the bodys nerves and blood cells healthy

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The generation of oxidative stress, characterized by an imbalance between the production of free radicals and the bodys antioxidant defenses, can lead to the activation and perpetuation of autoimmune responses [7]

In situations when the emergency provider is not X-waivered and next day follow-up cannot be guaranteed, the patient can be directed to return to the ED for subsequent doses of buprenorphine (up to 72 hours after initial presentation) until outpatient follow-up and long term MOUD can be established