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Novel Combination Therapy Induced Histological Remission in Patients with Refractory Ulcerative Colitis

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Ducray HAG, Globa L, Pustovyy O, Vodyanoy V, Sorokulova I

Therefore, the activities and trafficking of ATP7A and ATP7B are stringently controlled by intracellular copper concentrations, copper-binding proteins such as MTs, and multiple signaling pathways (La Fontaine and Mercer, 2007

Specifically, calcium-sensing receptors are elevated during infantile cholestasis, and their elevation enhances the activation of p-extracellular signal-regulated kinase (p-ERK) which in turn lessens the expression of apoptotic markers, lowers intracellular calcium, and also inhibits the development of oxidative stress (Qin et al., 2020)