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However, we found low heterogeneity between the five trials in all-cause mortality (I 2 = 22%) (Figure 2) and detected no heterogeneity between the two trials reporting heart failure (I 2 = 0%), unstable angina (I 2 = 0%), and myocardial reinfarction (I 2 = 0%) (Figure 3)

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184 PD is characterized by the loss of nigrostriatal dopaminergic neurons and a deficit in mitochondrial respiration

Eight studies [14, 1820, 22, 24, 27, 28] had a treatment period of 2 weeks, and the follow-up period of other studies still ranged variously

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