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Enhancement of anti-oxidant capacity: curcumin increases the levels of anti-oxidant enzymes such as catalase, superoxide dismutase, and glutathione in the nervous system, skeletal muscles, and circulatory system, mitigating oxidative stress [74]

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All I can say is that I'm basically a case of a doctor being indifferent by recommending a patient take vitamin b12 tablets in addition to b12 injections...which allowed a severe reaction to take place that is ongoing

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NAD + is a substrate for sirtuins, which regulate enzymes through post-translational deacylation by transferring the acetyl group of a target protein to NAD + 7,48