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An increased intestinal PEG-400 permeability in first-degree healthy relatives of Crohn's disease patients was described for the first time in 1986 (107), whereas three other studies could not reproduce these findings by using the same probe (108110)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 182.Norman K.C., Moore B.B., Arnold K.B., ODwyer D.N

With the advancement of research, the understanding of COPD etiology has expanded from exposure to harmful gases/particles to multiple etiological types. New classifications of COPD have emerged, including the pulmonary cachexia phenotype, COPD-bronchiectasis overlap phenotype, rapid progressive phenotype, non-smoking COPD phenotype, comorbidity/systemic phenotype, upper lobe-predominant emphysema phenotype, 1-antitrypsin deficiency phenotype, and early disease-related phenotypes (pre-COPD, early-onset COPD, preserved ratio impaired lung function) ( In contrast, an endotype represents the underlying biological or molecular mechanisms that produce these observable traits