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Adalimumab (ADA), etanercept (ETN), infliximab (INF), golimumab (GOL), and certolizumab pegol (CZB), are inhibitor of tumor necrosis factor (TNF), which are an indispensable part for the treatment of (RA), juvenile idiopathic arthritis, ankylosing spondylitis (AS), psoriatic arthritis, psoriasis (PS) and Crohns disease (CD) 7,8,9,10,11

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* Correspondence: Xindong Wang [email protected] These authors have contributed equally to this work and share first authorship Abbreviations AF, atrial fibrillation

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Cells were washed twice with PBS and fixed with 4% paraformaldehyde for 15 mins at room temperature

Notably, in the context of DKD, SIRT2 has a dual role