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For refractory cases, the definitive interventional treatment is advanced neuromodulation

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doi: 10.1016/j.radonc.2018.06.012 62 ChenD-CChenL-HJinW-DXuY-KXuP-J

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Sanchez et al

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The endo-lysosomal pathway is a major bottleneck limiting the clinical efficacy of therapeutic agents, as nanoparticles are often sequestered and degraded following endocytosis, reducing bioavailability ( in vitro , as evidenced by the dispersion of gene cargo around the nucleus and a transient peak in the colocalization coefficient followed by a decrease, indicating successful endosomal escape

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Kelly Dorfman MS, LND explains the impact of the antioxidant glutathione on autism

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