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Such reactions can range from responses with no clinical manifestations to irritating rashes to life-threatening conditions such as anaphylactic shock, which constricts breathing and impairs motor function

Allergic Reactions and Anaphylaxis In rare cases, more severe allergic reactions can occur

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Subchondral bone plate thickness is associated with micromechanical and microstructural changes in the bovine patella osteochondral junction with different levels of cartilage degeneration

However, clear evidence to establish a mechanistically prominent pathway remains yet to be established, as a limited number of studies to establish mechanistic pathways have been conducted on laboratory animals and humans

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