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Following activated PPAR binding to the RXR to form a heterodimer, there is binding to multiple specific response elements, leading to transcriptional activation of genes responsible for the pleotrophic effects of peroxisome proliferators (Green 1995

In particular, patients with monocytic AML are preferentially dependent on the anti-apoptotic protein MCL1 for OXPHOS activity (106)

The key driver of results is sustained supplementation over weeks rather than a single well-timed dose

250mg reduced glutathione, the body's master antioxidant per serving

Wait R, James B, Calder MR
