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Three authors (MM, AN, and JV) independently screened titles and abstracts following de-duplication

The therapeutic potential of these NAD analog inhibitors may be limited due to the inhibitory effect they may have in several other NAD dependent enzymes, which raises concerns about their specificity

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[2] Mechanistic studies suggest that AOD-9604 may upregulate the expression of 3-adrenergic receptors (3-AR) in adipocytes, with elevated 3-AR expression potentially contributing to augmented lipolytic sensitivity in adipose tissue

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