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Moreover, inconsistent study designs further complicate the clinical translation of findings
Li, 2022
In addition, it was found that in 12-O-tetradecanoylphorbol-13-acetate (2.5 g/ear)-induced ear edema mouse models, L-theanine could downregulate the expression of platelet endothelial adhesion molecule-1 (PECAM-1) and decrease the production of pro-inflammatory factors, including IL-1, tumor necrosis factor-alpha (TNF-), and COX-2, which were significantly expressed in neutrophils, thus improving the infiltration and activation of neutrophils (30)
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Recently, phytomedicine has shown prophylactic and therapeutic potential in PD due to its antioxidant [12,13,14], anti-inflammatory [15] and antiapoptotic effects [16, 17]
Tolerability and safety of a novel ketogenic ester, Bis-Hexanoyl (R)-1,3-Butanediol: a randomized controlled trial in healthy adults
