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Any comments submitted by July 9 will be formally provided to the PCAC members ahead of the meeting

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LPS binds to Tolllike receptor 4 (TLR4) on endothelial and immune cells, triggering the NFB inflammatory cascade and driving systemic inflammation [64, 65]

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76 KimH

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The excitotoxicity event is caused by excessive and unregulated activation of glutamate receptors

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4 Future directions Alogliptin presents itself as a promising drug for further development and repurposing for pathological conditions that may or may not be related to T2DM

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References Costell M, et al

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