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We uncovered that feminization of the germline results in significant lifespan extension at specific temperatures, but masculinization of the germline results in drastic lifespan shortening under all tested conditions (Fig

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Species-level analysis further identified an elevated presence of Lactobacillus Reuteri , Lactobacillus Johnsonii , and Helicobacter typhi , microbial species known to enhance IL-22 expression in ILC3s

GIP/GLP-1 dual agonists (tirzepatide) additionally engage the GIP receptor, adding a second incretin mechanism

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