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Based on the current studies, we cannot be certain as to whether ATF3-regulated endothelial cell death at the transcriptional level promotes ferroptosis mediated AS in response to atherogenic agents

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These pharmacokinetic challenges undermine its sustained efficacy, and the need for frequent dosing may elevate the risk of adverse effects, further limiting its clinical utility
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10.1038/s41588-020-0637-y [DOI] [PMC free article] [PubMed] [Google Scholar] 5.Krentz NAJ, Gloyn AL (2020) Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics
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